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Akkermansia muciniphila 2

Akkermansia muciniphila 1

Axin1 1

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NAFLD 1

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Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 667-685 doi: 10.1007/s11684-022-0960-z

Abstract: Akkermansia muciniphila (A. muciniphila) is a next-generation probiotic that has been reportedEmerging evidence indicates the therapeutic potential of A. muciniphila for NAFLD, especiallyHere, the current knowledge on the role of A. muciniphila in the progression of NAFLD was summarizedA. muciniphila abundancy is decreased in animals and humans with NAFLD.The modulation mechanisms by which A. muciniphila acts to improve hepatic inflammation are mainly

Keywords： Akkermansia muciniphila     NAFLD     NASH     steatosis     inflammation    

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Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD-1 immunotherapy

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 729-746 doi: 10.1007/s11684-022-0978-2

Abstract: Yes-associated protein 1 (YAP1) expression increased in liver tumor cells in early HCC, and Akkermansiamuciniphila abundance decreased in the colon.The response to anti-PD-1 treatment is associated with A. muciniphila abundance in many tumorsHowever, the interaction between A. muciniphila abundance and YAP1 expression remains unclearHere, anti-PD-1 treatment decreased A. muciniphila abundance in the colon, but increased YAP1

Keywords： hepatocellular carcinoma     YAP1     Akkermansia muciniphila     anti-PD-1     dihydroartemisinin     bile acid    

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Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Engineering doi: 10.1016/j.eng.2023.06.007

Abstract: altered goblet cell spatial distribution, PC morphology, reduced lysozyme expression, and enriched Akkermansiamuciniphila (A. muciniphila).Treatment with A. muciniphila reduced DSS-colitis severity.intestinal Axin1 protects against colitis, likely driven by epithelial Axin1 and Axin1-associated A. muciniphila

Keywords： Axin1     Bacteria     Microbiome inflammation     Inflammatory bowel disease     Immunity     Microbiome     Paneth cells     Akkermansiamuciniphila     Wnt    

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Title Author Date Type Operation

Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge

Journal Article

Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD-1 immunotherapy

Journal Article

Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Journal Article